When many distinct genetic pathways work together to produce a single or closely related trait, genetic heterogeneity is present. There are two forms of genetic heterogeneity: allelic heterogeneity, which happens when several alleles of the same gene generate a similar phenotype, and locus heterogeneity, which happens when various mutations at other loci give a similar phenotype. Numerous common human illnesses, such as cystic fibrosis, Alzheimer's disease, autism spectrum disorders, hereditary propensity for breast cancer, and non-syndromic hearing loss, are connected to considerable genetic variation on numerous levels of aetiology. These complicated layers of causation result from rare, individual mutations that when combined help to cause common illnesses, as well as the accumulation of several rare, Individual mutations within the same gene that cause the same common disease to manifest differently in various individuals; the accumulation of numerous uncommon individual mutations within the same gene that cause various phenotypic manifestations of the same common disease in various individuals; and the occurrence of the same common disease in various individuals as a result of various mutations. The creation of efficient preventative and therapeutic strategies for various diseases will be made easier by a better understanding of the function of genetic heterogeneity and the processes by which it generates common disease phenotypes.
Title : The impact of AI on the future of public health and preventative healthcare
David John Wortley, International Society of Digital Medicine (ISDM), United Kingdom
Title : Personalized and Precision Medicine (PPM) as a unique healthcare model to secure the human healthcare, wellness and biosafety through the view of public health, network-driven healthcare services and lifestyle management
Sergey Suchkov, National Center for Human Photosynthesis, Mexico
Title : Managing integration and interoperability of intelligent and ethical transformed health and social care ecosystems
Habil Bernd Blobel, University of Regensburg, Germany
Title : Study scalp electroacupuncture therapy for autism spectrum disorder
Zhenhuan Liu, University of Chinese Medicine, China
Title : Environmental Public Health Impact Assessment (EHIA) process for tobacco processing plants
Vijayan Gurumurthy Iyer, Techno-Economic- Environmental Study and Check Consultancy Services, India
Title : Therapeutic potential of Benincasa hispida extract in regulating metabolic markers among patients with type 2 diabetes
Wan Rosli Wan Ishak , University Science Malaysia, Malaysia