Alzheimer's disease (AD) is a neurological condition that typically develops gradually and gets worse over time. It is the root of 60–70% of dementia cases. The most prevalent initial sign is trouble recalling recent events. Language difficulties, disorientation (including a tendency to get lost easily), mood swings, a lack of desire, self-neglect, and behavioural problems can all be indicators of advanced Alzheimer's disease. As a person's health deteriorates, they frequently isolate themselves from friends and family. Body functions gradually deteriorate, which eventually results in death. The usual life expectancy upon diagnosis is three to nine years, however the rate of development might vary. It is unclear what causes Alzheimer's disease. There are several genetic and environmental risk factors connected to its development. The most potent genetic risk factor originates from an APOE allele. A history of head trauma, severe depression, and high blood pressure are additional risk factors. Amyloid plaques, neurofibrillary tangles, and a loss of neuronal connections in the brain are all major contributors to the disease process. Based on the patient's medical history, cognitive testing, imaging studies, and blood tests to rule out other potential reasons, a likely diagnosis is made. Initial symptoms are frequently confused with ageing processes. For a certain diagnosis, brain tissue examination is required, but this can only be done after someone has passed away. Healthy eating, exercise, and social interaction are all proven to promote ageing in general and may help lower the risk of cognitive decline and dementia.
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