Assessing human exposure to key chemical carcinogens diagnostic approaches and interpretation

Chemical carcinogens classified by the International Agency for Research on Cancer (IARC) as Group 1 very probably contribute to cancer occurrence in over 13.5 million people and death from cancer in over seven million people. In percent, chemical elements and chemical compounds very probably contribute to cancer occurrence in about 68% of all cancer cases and very probably significantly contribute to cancer death in about 72% of all cancer deaths (yearly and globally). There are two main reasons for increasing cancer cases in the next decades: first, growing of the world population and, second, un-proportional growing of the elderly population. Consequently, by 2050, the number of cancer cases predicts to reach 35 million. The mentioned chemical carcinogens were used for decades without proper evaluation of their health effects. Early detection is crucial as most carcinogens have cumulative effects. Identifying urinary markers of exposure can help detect, eliminate, or reduce sources of carcinogens, advancing preventive oncology. While complete eliminating carcinogens is impossible, improving detection and monitoring?especially through specialized urine analysis?can help define preventive measures to lower carcinogen levels in the body. Described screening protocol is applicable in any location with HPLC (High Performance Liquid Chromatography) and ICP (Inductively Coupled Plasma) devices. They are non-invasive, quick, effective, affordable, and inexpensive requiring only urine samples. This screening protocol aims to develop, improve, and implement screening protocol for many malignant diseases and some chronic non-communicable diseases like cardiovascular, endocrine, neurological, hematological, dermatological, and malignant diseases. It supports medical professionals in interpreting HPLC and ICP urinary analyses and providing guidance on reducing or avoiding carcinogen exposure. In some cases, doctors may identify sources of exposure and inform authorities to address and eliminate these hazards.