Personalized & Precision Medicine (PPM) as a unique avenue to secure national demographics and biosafety: Through global health to reach the personalized diet harmony and lifestyle wellness

A new systems approach to diseased states and wellness result in a new branch in the healthcare services, namely, personalized and precision medicine (PPM). To achieve the implementation of PPM concept, it is necessary to create a fundamentally new strategy based upon the subclinical recognition of biomarkers of hidden abnormalities long before the disease clinically manifests itself. Metabolomics (along with the other OMICS technologies) and nutritional research proved to be valuable tools for the measurement of biochemical changes associated health changes related to diet. It is also, highly, promising in identification of nutritional biomarkers to monitor nutritional intervention studies. The greatest challenge for metabolomics research is its integration with other omics and phenotypic data. This will enhance our knowledge of diet-health relationships. The latter requires collaboration among translational and clinical researchers with overlapping expertise areas including nutritionists, clinicians, nurses, bioinformaticians, statisticians and chemists, and many other stakeholders. This expertise integration is vital to develop the knowledge to establish the evidence-based PPM-based nutrition. The greatest challenge to cracking the relationships between food and health is to decipher the high interindividual variability responses to food intake. The new frontier of the nutritional sciences lies in our ability to predictably engineer our physiologic networks for diet, health, and disease. This will ultimately allow fine tuning of diet intervention and health monitoring. The goal of PPM-based nutrition is the design of customized nutritional recommendations to prevent or to treat nutrition-related disorders. Those strategies should include nutriogenomics information, other factors such as dietary and physical activity patterns, metabolome, and microbiota. Various genes and polymorphisms have been defined as relevant factors to explain diet-specific metabolic responses. The concept of PPM-based nutrition is to provide accurate nutritional recommendations for an individual to obtain a healthier lifestyle. An individual’s personal integrative nutritional biomarker profile can be combined with the identification of food ingredients to determine that individual’s PPM-based nutrition. Those advances are paving the way for the design of innovative strategies for the control of chronic diseases. PPM-based nutrition has the huge potential to maintain health, as a result of a rigorous nutrigenomic analysis whilst considering the genetic makeup of an individual. There is thus a need for the identification of novel nutritional biomarkers or patterns of biomarkers that link nutrition with health and will lead to further understanding the role of food in health and disease. This will be made possible by large genetic biobanks that are designed to capture genetic diversity. This is the reason for developing global scientific, clinical, social, and educational projects in the area of PPM to elicit the content of the new branch.

Sergey Suchkov was born in the City of Astrakhan, Russia, in a family of dynasty medical doctors. In 1980, graduated from Astrakhan State Medical University and was awarded with MD. In 1985, Suchkov maintained his PhD as a PhD student of the I.M. Sechenov Moscow Medical Academy and Institute of Medical Enzymology. In 2001, Suchkov maintained his Doctor Degree at the National Institute of Immunology, Russia. From 1989 through 1995, Dr Suchkov was being a Head of the Lab of Clinical Immunology, Helmholtz Eye Research Institute in Moscow. From 1995 through 2004 - a Chair of the Dept for Clinical Immunology, Moscow Clinical Research Institute (MONIKI). In 1993-1996, Dr Suchkov was a Secretary-in-Chief of the Editorial Board, Biomedical Science, an international journal published jointly by the USSR Academy of Sciences and the Royal Society of Chemistry, UK. At present, Dr Sergey Suchkov, MD, PhD, is: Professor, and Chair of the Dept for Personalized Medicine & Precision Nutriciology of the Institute for Global Health of RosBioTech, and Professor of Dept of Clinical Immunology, A.I. Evdokimov Moscow State Medical and Dental University (MGMSU), Russia; Secretary General, United Cultural Convention (UCC), Cambridge, UK. Dr. Suchkov is a member of the: New York Academy of Sciences, USA, American Chemical Society (ACS), USA; American Heart Association (AHA), USA; European Association for Medical Education (AMEE), Dundee, UK; EPMA (European Association for Predictive, Preventive and Personalized Medicine), Brussels, EU; ARVO (American Association for Research in Vision and Ophthalmology); SER (International Society for Eye Research); Personalized Medicine Coalition (PMC), Washington, DC, USA.