Title : Natural Family Planning through The View of Personalized and Precision Reproductive Healthcare: An Option for clinicians, geneticists and caregivers to realize the potential of genomics-informed care to secure the Individualized Human Biosafety and Planetary Demographics
Abstract:
The overall morbidity and mortality have decreased substantially in the early and pre-early pediatric diseases following advances in medical and surgical management for several devastating diseases. However, there has been little change in the incidence of developmental defects. Despite the heterogeneity in the etiology of pediatric diseases and developmental defects, there is a considerable overlap in the molecular and cellular pathways to open a green way for developing an upgraded strategy in diagnostics, prediction prognostication and monitoring.
The link that might exert reliable control over morbidity, mortality and disabling rates as well as significantly optimize the cost and efficacy of treatment for those who had fallen ill and for persons-at-risk is Personalized & Precision Medicine (PPM) as being the Grand Challenge to forecast, to predict and to prevent is rooted in a big and a new science generated by the achievements of systems biology and translational Medicine (TraMed).
To achieve the implementation of PPM concept into the daily practice (including Reproductology), it is necessary to create a new strategy based upon recognition and applications of Biomarkers in healthcare services. This strategy would give a real opportunity to secure preventive, prophylactic, therapeutic and rehabilitative measures, whose personalization could have a significantly positive influence on family planning, reproductology and demographics as a whole.
In this sense, we would need Centers for Personalized & Precision Pediatrics (CPPP) and Center for Precision Reproductology and Personalized Family Planning, designed to bring next-generation care to the intersexual pairs, pregnant women and children by using advanced technologies to understand the individualized unique genetic makeups and offer tailored treatments and to be developing novel diagnostic and predictive tools as well as newest therapeutics that target infertility and specific diseases and improve health.
For instance, the recently established at Columbia University Reproductive Precision Medicine Center develops and evaluates new genomic tests and treatments, and translates them into care. In the future, as the genes leading to the inborn defects are identified, medical and in-utero gene therapies may become possible.
The patients represent a wide cross-section of both normal and abnormal human pregnancies, sometimes from the pre-implantation embryo to the end of pregnancy. The information from these technologies allows individualized counseling and care based on the latest Hi Tech innovations.
The concept of PPM has been applied in reproductive medicine long before its popularization. The causes of infertility are various, and factors influencing the success rates of ART are complicated; hence, every step of reproductive medicine, such as the diagnosis of infertility causes and transfer of healthy embryos, needs to be precise.
Many individual factors influence fertility treatment decisions including your specific diagnosis, age, health status, and lifestyle. Meanwhile, fertility specialists already use specific genomic and phenomic biomarkers to help make the right preventive, prophylactic or treatment decisions.
One of the better known uses of PPM-related resources in reproductive medicine and family planning and female infertility is the genetic test that most accurately determines how receptive a woman’s endometrium (inner uterine lining) is for implanting an embryo. Male fertility problems are the cause of an infertility diagnosis among couples approximately half the time. In addition, many causes of male infertility remain unknown. As a result, genomics and proteomics represent examples of methods to investigate the molecular level of male infertility.
Reproductive PPM is at the preliminary stage of discovering and validating genomic, protein and metabolite biomarkers. Perhaps what is currently being offered as personalized treatment of infertile patient is more based on “the best expert opinion of the attending clinician” than “the best evidence-based data available”. Experts suggest there is room for improvement in both early diagnostics of male infertility and drug development. Further, PPM has potential for targeted diagnostic and therapeutic advances.
In brief, Reproductive PPM is at the preliminary stage of discovering and validating genomic, protein and metabolite biomarkers. In this sense, PPM and personalized and precision genomics as the major part of the latter are a new and exciting field with the potential to significantly improve medical care for pregnant women and children.
In this sense, PPM and personalized and precision genomics as the major part of the latter are a new and exciting field with the potential to significantly improve medical care for pregnant women and children. And PPM-based Reproductology and Personalized Genomics-related Armamentarium has been at the forefront of genomic technology adoption! And effectively integrating genomics into routine care will demonstrate the efficacy of a new molecular diagnostic or targeted therapeutic in controlled settings. So, developing reproductology-related expert competency in genomics is a daunting task, but one that the specialty can and must accomplish in the near future. Achieving such competency will provide effectively integrating genomics into practice, will improve reproductology-related experts’ efficacy in caring for the patient current health concerns and will make experts the guides to lifelong health.
For reproductive medicine, precision has always been a criterion in every procedure, including etiology-oriented examination, specific diagnosis, identifying healthy embryos, WOI, and accurate implantation. Combined with genetic information and a large volume of biomedical data, an unknown territory of reproductive medicine will be explored, and the mechanisms underlying the causes of infertility that we do not yet know will be elucidated. The application of PPM has become a guideline for the development of reproductive medicine.
Regarding the latter, there are several main needs that are relevant to care partners across disease settings include (1) information and guidance to prepare them for the role; (2) how to alleviate discomfort for the person with illness; (3) enhancing skills for the physical tasks of the role; (4) strategies for managing the psychological, and financial implications of the care partner role; and (5) assistance in advance care planning and on preparing for the care recipient's death. The individualized care partner coping is a result of complex interactions between stressors and mediators as they navigate chronic illness, but palliative providers with an understanding of these factors are well-positioned to address the risk factors and provide appropriate support.
The individualized family planning presents unique challenges to obstetrician-gynecologists. Improved access to contraception and abortion services is significantly lowering unintended pregnancies rates in adolescents, but more data assessing the effectiveness of interventions in marginalized communities are needed. In this context, personalized aims and objectives exist at every stage of disorder initiation and progression to develop a Personalized Health Plan addressing lifestyle, risk modification and disease management, and later, a Personalized Health Management & Wellness Program to be based on biomarkers of the next step generation combined with big data technology which would raise the prediction, prognostication and precision of identifying dysfunctions. Information on the genome, epigenetic groups, transcriptome, proteome, metabolome. SO, the precise and accurate molecular diagnosis can be integrated, and based on this information, screening and identification platforms can be established.
For instance, for prevention, the essence is avoiding the causes of infertility. Among all the causes of infertility, some are related to an unhealthy lifestyle. Strengthening education on female reproductive health will be a strong prevention for infertility. With our deepening understanding of different causes of infertility, more personalized diagnoses can be made, and more precise treatment can be given, and in this way, the success rate of ART can be improved. With the continued promotion of PPM and reproductive medicine will reach new heights and bring hope for more patients who are suffering from infertility.
SO, implementation of PPM into the areas of reproductive medicine and family planning requires a lot before the current model “physician-patient” could be gradually displaced by a new model “medical advisor-healthy person-at-risk”. This is the reason for developing global scientific, clinical, social, and educational projects in the area of PPM to elicit the content of the new branch.
