The COVID-19 pandemic has brought about significant changes in all areas of human life: the way we live, communicate, train, work, etc. The rapid spread of the virus in combination with the significant and unpleasant consequences for human health has been the trigger for a unique global collaboration in the scientific community to find a solution as soon as possible. At the same time, it has driven technological innovations at a frantic pace in order to support people, communities and enterprises operate. The unprecedented conditions created led to the need for social distancing and isolation in order to prevent further spread of the virus. In this context, the term "tele-" was added to almost any activity. Tele-work, tele-education and of course tele-health have been adopted in all their forms in order for people and businesses to face the new challenges. The new normality caused significant changes in the maturation of the public, eventually bending technophobia and technological illiteracy. The combination of mobile communications, smart phones, wearables and the Internet has created technological innovations that have come to stay. Mobile health (mHealth) is on the rise, providing important solutions to tackle the pandemic, proving its usefulness in all directions, bringing to the fore many start-ups. However, issues of personal data protection, privacy, confidentiality of sensitive health data, etc., remain open in order to support the continuity of health care in compliance with applicable national legislations.